1. have charge of sth [sb] 负责照顾或管理某物或某人。
如：He has charge of the branch.
Doctors have charge of sick people.
2. in charge of 负责管理，主管。
如：Mr Smith is in charge of the factory.
Mary is in charge of the children.
注：有时可以不出现 of 短语。
如：Who is in charge here?
3. in the charge of 在……的管理(负责)之下。
如：The factory is in the charge of my father.
比较：Mr Smith is in charge of our class. ＝Our class is in the charge of Mr Smith.
注：in the charge of 中的介词 in 有时可换为 under。
如：The baby is under the charge of her.
4. take charge of 管理，负责。
如：Soon he will take charge of the department.
The department was badly organized until she took charge(of it).
5. charge some money for sth 因为某事物而索取钱。
如：How much do you charge for a room with a bath?
They’ll charge at least 50 dollars for doing it.
注：若要指明是向谁而索，可在 charge 后加 sb。
如：He charged me five dollars for this magazine.
I’m not going there again --- they charged me $2foracup of coffee.
6. charge sb with sth . 指控某人做某事，因为某事而控告某人。
如：She charged him with cheating.
The police are going to charge him with murder.
如：He was charged with stealing. 他被指控偷盗。